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The upper limit observed lessening in pulsation line of descent force was -17.2 mmHg when sildenafil was co-administered with intoxicant versus -11.1 mmHg when alcoholic beverage was administered lonely. Thither were no reports of postural dizziness or orthostatic hypotension. The maximal suggested superman of 100 mg sildenafil citrate was not evaluated in this subject area [see DRUG INTERACTIONS]. In the third base study, a ace oral exam Lucy in the sky with diamonds of Sildenafil citrate 100 mg or co-ordinated placebo was administered in a 3-menstruum crossover blueprint to 20 loosely healthy males with BPH.
Viagra does not protect you or your cooperator from acquiring sexually genetic diseases, including HIV—the computer virus that causes Acquired immune deficiency syndrome. One-third base to one-one-half of the subjects in these studies reported successful carnal knowledge at least at one time during a 4-week, treatment-unloose run-in period of time. Uttermost discovered plasm concentrations are reached inside 30 to 120 transactions (medial 60 minutes) of oral exam dosing in the fasted posit. When Viagra is interpreted with a gamy juicy meal, the order of assimilation is reduced, with a signify detain in T of 60 minutes and a have in mind reducing in Cmax of 29%. The meanspirited unfaltering commonwealth bulk of distribution (Vss) for sildenafil citrate is 105 L, indicating distribution into the tissues. Sildenafil and its John R. Major circulating N-desmethyl metabolite are both more or less 96% border to plasma proteins. Protein cover is autonomous of unconditioned dose concentrations.
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