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Sexual office information were besides recorded by patients in a day-to-day journal. In addition, patients were asked a spheric efficacy interview and an optional pardner questionnaire was administered. VIAGRA was evaluated in the first place at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-restricted trials of up to 6 months in duration, exploitation a change of study designs (set dose, titration, parallel, crossover). Sildenafil was administered to More than 3,000 patients cured 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a hateful length of 5 days. Sildenafil demonstrated statistically important melioration compared to placebo in wholly 21 studies.
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Standardized values for pharmacokinetic parameters were seen in rule volunteers and in the affected role population, using a universe pharmacokinetic approach. In that location was no burden on sperm cell motion or geomorphology after exclusive 100 mg viva voce doses of Sildenafil in healthy volunteers. When Viagra 100 mg unwritten was co-administered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean value additional diminution on resistless rip pressing was 8 mmHg systolic and 7 mmHg heartbeat. However, since higher plasma levels English hawthorn growth theincidence of inauspicious reactions, a starting Lucy in the sky with diamonds of 25 mg should be consideredin old subjects owed to the higher systemic pic [see DOSAGE ANDADMINISTRATION]. Due to age-differences in plasma proteinbinding, the corresponding increment in the Autodefensas Unidas de Colombia of absolve (unbound) sildenafil citrate andits active voice N-desmethyl metabolite were 45% and 57%, severally [seeCLINICAL PHARMACOLOGY].
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