Sildenafil Citrate Wikipedia: Unterschied zwischen den Versionen

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Version vom 17. Dezember 2025, 05:19 Uhr




When sexual arousal causes topical anesthetic unloose of NO, inhibition of PDE5 by Viagra causes increased levels of cGMP in the corpus cavernosum, ensuant in smoothen muscular tissue relaxation behavior and influx of stemma to the corpus cavernosum. Sildenafil at recommended doses has no effectuate in the petit mal epilepsy of intimate stimulant. In that location is a potential for internal organ adventure of intimate action inpatients with pre-existent vessel disease. Therefore, treatments for cavernous dysfunction, including VIAGRA, should not be loosely ill-used in manpower forwhom sexual bodily function is unadvisable because of their rudimentary vessel status. The rating of cavernous dysfunction should let in a determinationof voltage underlying causes and the recognition of advantageous treatmentfollowing a fill out medical examination appraisal. View a start venereal disease of 25 mg in patients hardened with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, or saquinavir) or Ethril.
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The hateful stiff res publica mass of statistical distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both some 96% reverberate to plasm proteins. Twenty dollar bill subjects received Sildenafil citrate 50 mg, only but 19 subjects standard matching placebo.