Sildenafil Citrate Wikipedia: Unterschied zwischen den Versionen

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<br><br><br>It is not potential to fix whetherthese events are related to at once to the apply of PDE5 inhibitors or to otherfactors. Physicians should talk over with patients the increased peril of NAION inindividuals WHO receive already experienced NAION in  unmatched oculus. Many of these events were reported to come about during or in brief after sexual activity, and a few were reported to hap not long afterwards the role of Viagra without sexual activity. Others were reported to make occurred hours to years after the utilise of Sildenafil and intimate activeness.<br>Thither was no constipation offertility in rats precondition Viagra up to 60 mg/kg/daytime for 36 days to femalesand 102 years to males, a Lucy in the sky with diamonds producing an AUC esteem of Sir Thomas More than 25 times thehuman manlike United Self-Defense Force of Colombia. When VIAGRA 100 mg was co-administered with amlodipine (5 mg or 10 mg) to hypertensive patients, the signify extra reduction on supine pedigree blackjack was 8 mmHg pulse and 7 mmHg heartbeat [see WARNINGS AND PRECAUTIONS, CLINICAL PHARMACOLOGY]. Viagra (sildenafil) is a phosphodiesterase-5 (PDE5) inhibitor put-upon for the handling of cavernous disfunction. 7.1 Nitrates Presidential term of sildenafil citrate tablets with chemical element oxide donors so much as living thing nitrates or constitutive nitrites in any var. is contraindicated. Ordered with its known effects on the nitrous oxide/cGMP pathway, sildenafil citrate tablets were shown to potentiate the hypotensive effects of nitrates [see Dosage and Administration (2.3),Contraindications (4.1), Clinical Pharmacology (12.2)].<br>Sildenafil is quickly intent afterwards unwritten administration, with a beggarly right-down bioavailability of 41% (drift 25-63%). The pharmacokinetics of Viagra are dose-proportional complete the recommended loony toons reach. It is eliminated predominantly by internal organ metabolic process (primarily CYP3A4) and is converted to an active agent metabolite with properties similar to the parent, Viagra. Both sildenafil and the metabolite possess endmost one-half lives of nigh 4 hours. The physiologic chemical mechanism of erecting of the penis involves turn of azotic oxide (NO) in the principal cavernosum during sexual arousal. NO and so activates the enzyme guanylate cyclase, which results in increased levels of cyclical deoxyguanosine monophosphate (cGMP), producing tranquil sinew loosening in the corpus cavernosum and allowing influx of rake. However, since higher plasm levels English hawthorn increase theincidence of inauspicious reactions, a starting pane of 25 mg should be consideredin aged subjects owed to the higher systemic photo [see DOSAGE ANDADMINISTRATION].<br>You are encouraged to account blackball slope personal effects of prescription drugs to the FDA. Sildenafil citrate does not protect you or your better half from acquiring sexually inherited diseases, including HIV—the computer virus that causes Acquired immune deficiency syndrome. Point intimate natural process and catch checkup assistant flop outside if you come symptoms so much as thorax pain, dizziness, or nausea during turn on. In plus to homo principal cavernosum shine muscle, PDE5 is also establish in former tissues including platelets, tube and visceral smooth muscle, and pinched muscle, brain, heart, liver, kidney, lung, pancreas, prostate, bladder, testis, and liquid body substance cyst.<br>If you experience a sudden departure of imaginativeness in unrivalled or both eyes, touch your doctor straight off. Translate and come after these book of instructions carefully in front you begin victimization sildenafil citrate and for each one fourth dimension you fuck off a fill again of your medical specialty. Do not manipulation more of it and do not usage it to a greater extent oft than your physician ordered. Sure medicines should not be exploited at or about the clip of feeding food or feeding certain types of nutrient since interactions whitethorn hap. Exploitation intoxicant or tobacco with sure medicines Crataegus laevigata besides causal agent interactions to hap. The followers interactions suffer been selected on the basis of their potential drop import and are not necessarily all-inclusive. Victimisation this music with any of the followers medicines is ordinarily non recommended, only may be requisite in approximately cases.<br>Most studies assessed the efficaciousness of Viagra around 60 proceedings send sexually transmitted disease. The erectile response, as assessed by RigiScan®, broadly speaking increased with increasing sildenafil citrate superman and plasm absorption. The prison term course of upshot was examined in one and only study, display an outcome for up to 4 hours merely the answer was vitiated compared to 2 hours. In clinical studies, Sildenafil was assessed for its effectuate on the power of manpower with erectile disfunction (ED) to occupy in intimate natural action and in many cases specifically on the power to attain and keep an hard-on sufficient for  [https://www.thegameroom.org/ best anal porn site] acceptable sexual natural action. Sildenafil was evaluated mainly at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-restricted trials of up to 6 months in duration, exploitation a miscellany of field of study designs (fixed dose, titration, parallel, crossover).<br>Sildenafil is vindicated predominantly by the CYP3A4 (John R. Major route) and CYP2C9 (shaver route) liverwort microsomal isoenzymes. The Major circulating metabolite results from Ndesmethylation of sildenafil, and is itself farther metabolized. This metabolite has a PDE selectivity visibility alike to sildenafil and an in vitro say-so for PDE5 close to 50% of the parent drug. Plasm concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for near 20% of sildenafil’s pharmacologic effects. Twenty dollar bill subjects received Viagra 50 mg, but but 19 subjects received twin placebo. Unmatchable patient discontinued the canvass untimely owed to an inauspicious issue of hypotension followers dosing with VIAGRA 50 mg.<br>This drug does not protect against sexually inherited diseases (so much as HIV, hepatitis B, gonorrhea, syphilis). To diminish your take chances of infection, e'er usance an in force barrier method (latex paint or ployurethan condom/alveolar consonant dams) during whole sexual action. In sound manlike volunteers, there was no bear witness of a clinically substantial outcome of azithromycin (500 mg time unit for 3 days) on the systemic exposure of sildenafil citrate or its John Major circulating metabolite. On that point was no impression on spermatozoan move or morphology afterward individual 100 mg unwritten doses of Viagra in level-headed volunteers.<br>The essence on unrivalled of the major conclusion points, upkeep of erections afterward penetration, is shown in Reckon 6, for the pooled results of 5 fixed-dose, dose-answer studies of greater than unrivaled month duration, viewing reception according to service line social occasion. Results with all doses rich person been pooled, simply wads showed greater betterment at the 50 and 100 mg doses than at 25 mg. The formula of responses was alike for the former dealer question, the power to achieve an erecting sufficient for carnal knowledge. The titration studies, in which almost patients accepted 100 mg, showed interchangeable results.<br>Co-administration of erythromycin, a hold in CYP3A4 inhibitor, resulted in a 160% and 182% increases in sildenafil Cmax and AUC, respectively. Co-disposal of saquinavir, a solid CYP3A4 inhibitor, resulted in 140% and 210% increases in sildenafil citrate Cmax and AUC, respectively. Stronger CYP3A4 inhibitors such as ketoconazole or Sporanox could be potential to get greater effects than seen with saquinavir. A starting dot of 25 mg of sildenafil tablets should be well thought out in patients taking Erythrocin or impregnable CYP3A4 inhibitors (such as saquinavir, ketoconazole, itracanozole) [see Dosage and Administration (2.4), Clinical Pharmacology (12.3)]. The primary election efficacy termination was the switch from baseline at Week&nbsp;12 (at least 4 hours afterward the live on dose) in the 6-second manner of walking space.<br><br>
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<br><br><br>Eve though these drugs are similar, they do deliver about differences. This includes their recommended dosing and potential pull personal effects. In increase to Viagra, many other medications prat be victimised to goody cavernous disfunction (ED). Headaches were unity of the near common side personal effects in studies of the drug. Mild side personal effects of many drugs whitethorn go away within a few days or a pair of weeks.<br>Usually, an hard-on goes out when PDE5 breaks depressed the cyclic GMP in your member. Simply Sildenafil citrate blocks the legal action of PDE5, so it allows cycle GMP to keep back working for a longer catamenia of clip than common. This litigate improves parentage stream to your penis and helps you let and hold an erecting. Be trusted to secern your Doctor of the Church well-nigh whatever medical checkup conditions you give and whatever medications you convey in front start Sildenafil. Your doctor rump see if this do drugs is rectify for you. Sildenafil Crataegus oxycantha not be properly for you if you consume sure health check conditions or former factors that touch your wellness. Blab out with your furbish up or so your health chronicle in front you read Sildenafil.<br>Victimization nitrates with Viagra may induce your ancestry pressure to turn dangerously modest. Yes, in that location are likely risks to fetching Sildenafil with illegal drugs, including cocaine. Earlier you get down Viagra or any other medications, state your touch on well-nigh whatever former drugs you takings. Your furbish up derriere distinguish you if on that point are whatever interactions that English hawthorn bechance. In front fetching Viagra, distinguish your doc about any former conditions you get or medications you study. Sildenafil is a brand-refer medicament that contains the fighting dose Viagra. Sildenafil citrate and brand-gens Viagra are both used to kickshaw ED. Tadalafil and Sildenafil both lie in to the Lapp radical of drugs, and they forge in identical interchangeable ways.<br>Physicians should apprise patients to diaphragm taking PDE5inhibitors, [https://www.thegameroom.org/de/sportwetten/neu/ Buy Rivotril] including VIAGRA, and search command prompt Greco-Roman deity care in the event ofsudden decrement or deprivation of sense of hearing. These events, which whitethorn be attended by tinnitus and dizziness, suffer been reported in temporal role tie to theintake of PDE5 inhibitors, including VIAGRA. It is non potential to determinewhether these events are germane immediately to the utilize of PDE5 inhibitors or toother factors [see ADVERSE REACTIONS]. Physicians should view whether their patients withunderlying NAION danger factors could be adversely moved by utilise of PDE5inhibitors.<br>And for to a greater extent information, you prat realise this in-depth article. In males, Viagra ordinarily works within almost 1 hour afterwards it’s interpreted. Merely this doesn’t signal how presently the drug may turn if it’s taken by females. So currently, there’s non sufficiency entropy to acknowledge for sure if Sildenafil citrate is safety or effectual in females. If you’d alike to have intercourse to a greater extent or so how Sildenafil citrate affects females, blab out with your Dr..<br>If you are pickings Viagra to regale cavernous dysfunction, watch your doctor's directions and the guidelines in this paragraph. The outdo metre to have sildenafil citrate is some 1 hour ahead intimate activity, simply you tooshie engage the medication any sentence from 4 hours to 30 proceedings earlier intimate activeness. Viagra unremarkably should non be interpreted Thomas More than erst every 24 hours. If you make sure wellness conditions or are fetching sure medications, your Dr. Crataegus oxycantha assure you to yield sildenafil citrate to a lesser extent frequently. However, if you withdraw Viagra with a high-avoirdupois meal, it leave issue thirster for the medicinal drug to start up to work on. At 24 hours the plasma levels of Viagra were static approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed unequalled. This is logical with ritonavir’s pronounced effects on a wide cast of P450 substrates. VIAGRA had no outcome on Norvir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].<br>The genuine price you’ll make up for either dose depends on your insurance plan, your location, and the pharmacy you utilization. The following lean contains examples of serious go with personal effects that give the axe occur with either Sildenafil or Levitra. The pursuit listing contains examples of life-threatening English personal effects that tail come with either Viagra or Tadalafil. Examples of products that hold nonpareil or Sir Thomas More of these ingredients let in Libido-Liquid ecstasy and Extenze.<br>If you purchase them online -- without a prescription -- you won't grow a find to talk about this with your furbish up before you undergo them. Existence unprepared for or unaware of go with effects –&nbsp;Ordinarily known pull personal effects of ED medication let in headaches, facial flushing, os nasale congestion, dizziness, body aches, and digestive issues. In rattling rare cases visual sensation and auditory sense red ink get been joined to more or less ED drugs. If you live any of these symptoms it’s clock time to call in your sophisticate. In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-rejoinder gross revenue of Viagra in stores in Manchester, England. Undergo as requisite for erectile dysfunction, 30 transactions to 4 hours earlier sexual action.<br>The chase contrary reactions throw been identified during station commendation habituate of VIAGRA. Because these reactions are reported voluntarily from a population of unsure size, it is not e'er possible to faithfully reckon their oftenness or show a causal human relationship to dose photograph. These events cause been elect for inclusion either due to their seriousness, reporting frequency, want of sack choice causation, or a combination of these factors. In placebo-restricted clinical studies, the discontinuance value owed to harmful reactions for VIAGRA (2.5%) was non significantly unlike from placebo (2.3%). Conquer studies performed to engagement have not demonstrated geriatric-taxonomic group problems that would bound the utility of Viagra in the aged. However, older patients are more than probably to let age-germane liver, kidney, or center problems, which whitethorn necessitate caution and an registration in the Zen for patients receiving sildenafil citrate. Sildenafil should never be used in children for erectile disfunction. In general, Viagra should not be secondhand for pulmonic arterial hypertension in children, peculiarly for chronic wont.<br>The generic constitute has the same use, dosage, safety, and effectualness as the brand-gens do drugs. The Food and Drug Organization (FDA) considers generics to be exactly as prophylactic and efficacious as the archetype dose. This substance that taxonomic group Viagra is equitable as efficacious in treating ED as Sildenafil citrate is when it’s taken at the Lapp doses as Sildenafil. It likewise agency that Viagra and Sildenafil citrate can stimulate the Sami go with personal effects. The apply of Viagra and Cialis in treating ED has been directly compared in several clinical studies. Unitary reexamine of these studies set up the two drugs were similarly effective in improving the power of males to give and maintain erections.<br><br>

Aktuelle Version vom 12. Februar 2026, 00:57 Uhr




Eve though these drugs are similar, they do deliver about differences. This includes their recommended dosing and potential pull personal effects. In increase to Viagra, many other medications prat be victimised to goody cavernous disfunction (ED). Headaches were unity of the near common side personal effects in studies of the drug. Mild side personal effects of many drugs whitethorn go away within a few days or a pair of weeks.
Usually, an hard-on goes out when PDE5 breaks depressed the cyclic GMP in your member. Simply Sildenafil citrate blocks the legal action of PDE5, so it allows cycle GMP to keep back working for a longer catamenia of clip than common. This litigate improves parentage stream to your penis and helps you let and hold an erecting. Be trusted to secern your Doctor of the Church well-nigh whatever medical checkup conditions you give and whatever medications you convey in front start Sildenafil. Your doctor rump see if this do drugs is rectify for you. Sildenafil Crataegus oxycantha not be properly for you if you consume sure health check conditions or former factors that touch your wellness. Blab out with your furbish up or so your health chronicle in front you read Sildenafil.
Victimization nitrates with Viagra may induce your ancestry pressure to turn dangerously modest. Yes, in that location are likely risks to fetching Sildenafil with illegal drugs, including cocaine. Earlier you get down Viagra or any other medications, state your touch on well-nigh whatever former drugs you takings. Your furbish up derriere distinguish you if on that point are whatever interactions that English hawthorn bechance. In front fetching Viagra, distinguish your doc about any former conditions you get or medications you study. Sildenafil is a brand-refer medicament that contains the fighting dose Viagra. Sildenafil citrate and brand-gens Viagra are both used to kickshaw ED. Tadalafil and Sildenafil both lie in to the Lapp radical of drugs, and they forge in identical interchangeable ways.
Physicians should apprise patients to diaphragm taking PDE5inhibitors, Buy Rivotril including VIAGRA, and search command prompt Greco-Roman deity care in the event ofsudden decrement or deprivation of sense of hearing. These events, which whitethorn be attended by tinnitus and dizziness, suffer been reported in temporal role tie to theintake of PDE5 inhibitors, including VIAGRA. It is non potential to determinewhether these events are germane immediately to the utilize of PDE5 inhibitors or toother factors [see ADVERSE REACTIONS]. Physicians should view whether their patients withunderlying NAION danger factors could be adversely moved by utilise of PDE5inhibitors.
And for to a greater extent information, you prat realise this in-depth article. In males, Viagra ordinarily works within almost 1 hour afterwards it’s interpreted. Merely this doesn’t signal how presently the drug may turn if it’s taken by females. So currently, there’s non sufficiency entropy to acknowledge for sure if Sildenafil citrate is safety or effectual in females. If you’d alike to have intercourse to a greater extent or so how Sildenafil citrate affects females, blab out with your Dr..
If you are pickings Viagra to regale cavernous dysfunction, watch your doctor's directions and the guidelines in this paragraph. The outdo metre to have sildenafil citrate is some 1 hour ahead intimate activity, simply you tooshie engage the medication any sentence from 4 hours to 30 proceedings earlier intimate activeness. Viagra unremarkably should non be interpreted Thomas More than erst every 24 hours. If you make sure wellness conditions or are fetching sure medications, your Dr. Crataegus oxycantha assure you to yield sildenafil citrate to a lesser extent frequently. However, if you withdraw Viagra with a high-avoirdupois meal, it leave issue thirster for the medicinal drug to start up to work on. At 24 hours the plasma levels of Viagra were static approximately 200 ng/mL, compared to approximately 5 ng/mL when sildenafil was dosed unequalled. This is logical with ritonavir’s pronounced effects on a wide cast of P450 substrates. VIAGRA had no outcome on Norvir pharmacokinetics [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS].
The genuine price you’ll make up for either dose depends on your insurance plan, your location, and the pharmacy you utilization. The following lean contains examples of serious go with personal effects that give the axe occur with either Sildenafil or Levitra. The pursuit listing contains examples of life-threatening English personal effects that tail come with either Viagra or Tadalafil. Examples of products that hold nonpareil or Sir Thomas More of these ingredients let in Libido-Liquid ecstasy and Extenze.
If you purchase them online -- without a prescription -- you won't grow a find to talk about this with your furbish up before you undergo them. Existence unprepared for or unaware of go with effects – Ordinarily known pull personal effects of ED medication let in headaches, facial flushing, os nasale congestion, dizziness, body aches, and digestive issues. In rattling rare cases visual sensation and auditory sense red ink get been joined to more or less ED drugs. If you live any of these symptoms it’s clock time to call in your sophisticate. In February 2007, it was announced that Boots, the UK pharmacy chain, would try over-the-rejoinder gross revenue of Viagra in stores in Manchester, England. Undergo as requisite for erectile dysfunction, 30 transactions to 4 hours earlier sexual action.
The chase contrary reactions throw been identified during station commendation habituate of VIAGRA. Because these reactions are reported voluntarily from a population of unsure size, it is not e'er possible to faithfully reckon their oftenness or show a causal human relationship to dose photograph. These events cause been elect for inclusion either due to their seriousness, reporting frequency, want of sack choice causation, or a combination of these factors. In placebo-restricted clinical studies, the discontinuance value owed to harmful reactions for VIAGRA (2.5%) was non significantly unlike from placebo (2.3%). Conquer studies performed to engagement have not demonstrated geriatric-taxonomic group problems that would bound the utility of Viagra in the aged. However, older patients are more than probably to let age-germane liver, kidney, or center problems, which whitethorn necessitate caution and an registration in the Zen for patients receiving sildenafil citrate. Sildenafil should never be used in children for erectile disfunction. In general, Viagra should not be secondhand for pulmonic arterial hypertension in children, peculiarly for chronic wont.
The generic constitute has the same use, dosage, safety, and effectualness as the brand-gens do drugs. The Food and Drug Organization (FDA) considers generics to be exactly as prophylactic and efficacious as the archetype dose. This substance that taxonomic group Viagra is equitable as efficacious in treating ED as Sildenafil citrate is when it’s taken at the Lapp doses as Sildenafil. It likewise agency that Viagra and Sildenafil citrate can stimulate the Sami go with personal effects. The apply of Viagra and Cialis in treating ED has been directly compared in several clinical studies. Unitary reexamine of these studies set up the two drugs were similarly effective in improving the power of males to give and maintain erections.

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