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In 1994, Pfizer scientists revealed that sildenafil, which also inhibits the PDE5 enzyme, caused penile erection in males active in a clinical read of a warmheartedness medicate. Although ICOS scientists were not examination chemical compound IC351 for treating ED, they accepted its electric potential utility for treating that unhinge. Soon, in 1994, ICOS accepted a plain for combine IC351 (structurally dissimilar Viagra and vardenafil), and Phase 1 clinical trials began in 1995.