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Although taxonomic group interactions experience not been studied, early CYP3A4 inhibitors, including Citrus paradisi succus would probable addition vardenafil photograph. Ritonavir (600 mg b.i.d.) co-administered with Levitra 5 mg resulted in a 49-sheep pen increment in Levitra AUC and a 13folding increment in vardenafil Cmax. The fundamental interaction is a result of block liverwort metabolism of vardenafil by ritonavir, a HIV peptidase inhibitor and a extremely strong CYP3A4 inhibitor, which besides inhibits CYP2C9.